SUPPLEMENTAL MATERIAL Complementary proteomics methods identify novel components localizing asymmetrically to centrosomes
نویسندگان
چکیده
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Campusvej 55, DK-5230 Odense, Denmark. School of Biotechnology, AlbaNova University Center, Royal Institute of Technology (KTH), Roslagstullsbacken 21, SE-10691 Stockholm, Sweden. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
منابع مشابه
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Centrosomes in animal cells are dynamic organelles with a proteinaceous matrix of pericentriolar material assembled around a pair of centrioles. They organize the microtubule cytoskeleton and the mitotic spindle apparatus. Mature centrioles are essential for biogenesis of primary cilia that mediate key signalling events. Despite recent advances, the molecular basis for the plethora of processes...
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Centrioles are essential for the formation of centrosomes and cilia. While numerical and/or structural centrosomes aberrations are implicated in cancer, mutations in centriolar and centrosomal proteins are genetically linked to ciliopathies, microcephaly, and dwarfism. The evolutionarily conserved mechanisms underlying centrosome biogenesis are centered on a set of key proteins, including Plk4,...
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